Abstract
Seven Nocardia isolates from six patients were tested for in vitro susceptibility to sulfonamides, trimethoprim (TMP) and minocycline (MINO).
Minimal inhibitory concentration (MIC) values against Nocardia species were in the range between 1.56-12.5μg of sulfonamides/ml, 6.25-25μg of TMP/ml, 0.20-3.13μg of MINO/ml, Sulfamethoxazole (SMX) showed lowest MIC values among the five sulfonamides, and synergistic activities between TMP and sulfonamides were observed.
A clinical study of these six patients revealed three patients with pulmonary infection, two with skin infection and one with both. Six patients were treated with TMP-SMX, MONO or MINO plus SMX, and all showed improvement.
As we have effective drugs against nocardiosis, early diagnosis and early treatment, are essential.
