Abstract
The present paper deals with a part of the series of the author's studies on experimental arsenious poisoning.
Experiments were made by injecting Thiols (3% Sodium mercaptoacetate and BAL) intramuscularly into the thigh of mice, inbred strain ddY, which were given 1% arsenious acid solution into the stomach.
Author studied on concentration of erythrocytes, leukocytes, hemoglobin, and blood pictures of mice. After mice were killed by ether, their specimens were stained by Hematoxylin and partly Sudan III and Scharlachrot. For histochemical studies, Schumacher's method was used.
The following results were obtained.
(1) On findings of blood, Thiols were seemed to be effective in treatment of arsenious poisoning.
(2) On histological findings, 3% Sodium mercaptoacetate, monothiol, did not show so remarkable changes, but 12mg/kg.day of BAL, dithiol, showed slight damage of the liver and the kidneys.
(3) Arseic granule was not detected in any organs of almost all experimental animals after injection of Thiols.
(4) 0.04cc/kg.day of 3% Sodium mercaptoacetate and 6mg/kg.day of BAL were seemed to be effective in treatment of arsenious poisoning, but high doses f BAL should be used cautiously.
