Abstract
By using anti-cancer preparations Azan M, Nitromin, TESPA and Carzinophilin on subcutaneously implanted Ehrlich's ascites cancer cells and NFC (Nakahara-Fukuoka-Cancer) changes of size, tissue respiration of tumor and liver preparations were measured together with histopathological and electron-microscopy studies, The following results were obtained.
A) The sizes of tumors were diminished in anti-cancer preparation treated cases.
B) Tissue Respiration
1) Animal Experiments
i) Physiological saline was injected daily in tumor implanted mice but no significant difference was seen with the controls.
ii) Anti-cancer preparations were used on healthy mice and the tissue respiration of their livers were measured. No significant difference was seen with non-treated healthy animals.
iii) Liver tissue respiration of tumor implanted mice of heathly animals.
iv) As a result of anti-cancer treatment with Azan M, TESPA, Carzinophilin, the tissue _??_espiration of tumors was lowered in comparison to controls but the liver respiration showed no significant difference.
v) Nitromin lowered both the respiration of tumor and liver tissues.
2) Clinical Cases
i) The tissue respiration of stomach cancer tissue when compared to non-cancerous stomach tissue was increased in cases where no chemotherapy was used.
ii) The tissue respiration of stomach cancer tissues was decreased compared to controls when Azan M, Nitromin and carzinophilin were used.
C) Although no clear-cut changes were not seen in histopathological preparations in animal and clinical cases after use of drugs there were some cases where degeneration and abnormal mitosis of nuclei and fibrosis were seen.
D) Deformation, shrinkage and vacuolation of the mitochondria were seen in drug treated animal and clinical cases under electron microscopy.
