Aging, Diseases and Sports from the Aspect of Cell Clearance System, Autophagy

抄録

Macroautophagy, which literally means self-eating, constitutes one of two major intracellular proteolytic systems in eukaryotic cells along with the ubiqutin-proteasome. Our previous studies imply that inclusion bodies formed as a result of autophagy impairment are deeply associated with the pathogenic mechanism of human diseases. Recent studies have suggested that autophagy is also related to longevity and sarcopenia. It seems important to develop exercise/sports practical program for maintaining muscles in elder people from the aspect of regulation of autophagy. Efforts for this goal may eventually give a hint how to live longer and healthy.