A Case of Kawasaki Disease Complicated with Acute Pancreatitis After Steroid Pulse Therapy

Abstract

A 2-year-5-month-old boy fulfilled the diagnostic criteria for Kawasaki disease (KD) on the second day of illness, and intravenous immunoglobulin (IVIG) administration was immediately started. The response was insufficient and additional IVIG and intravenous methylprednisolone pulse (IVMP) administration was performed. The IVMP was effective. However, 6 days after administration, serum amylase level, serum lipase and elastase I increased and acute pancreatitis was diagnosed. The cause of pancreatitis in the present patient was likely related to the histological inflammatory changes in the pancreas due to severe vasculitis and cholestasis, as well as the influence of IVMP. Careful observation is required for patients with KD who have abdominal pain after IVMP.