Studies of Intravenous Fe⁵⁹ Globulin

Report 3. Application to Evaluation of Intravenous Bone Marrow Therapy

Abstract

Experimental intravenous Fe⁵⁹ globulin has been used quite widely and is now being applied to clinical hematological cases. In our experiments with rabbits and dogs we have found this metbod to be a more accurate reflection of the haemopoetic function when compared to other methods used. (Report 1) With experimental anemias prolongation of plasma clearance and lowering of utilization rate was seen. (Report 2) Intravenous cysteine was found to promote early return to normal values of plasma clearance and utilization rates and prevention of irradiation injury was very evident showing relatively good results even with immediate administeration of cysteine after irradiation. (Report 3) When intravenous Fe⁵⁹ was applied to intravenous bone marrow therapy in rabbits plasma clearance and utilization rate was near nornal showing the effectiveness of this method. In dogs the recovery time to T/2 values of plasma clearance was increased and the white blood cell count was relatively well stabilized.