Studies on the Serum Sialic Acid Levels in Various Diseases.

Abstract

1. The method of the tryptophane-perchloric acid reaction by Seibert and his associates was used to determine serum sialic acid levels in various discases. The author obtained results similar to other methobs. 2. The parallel increase of sialic acid, protein-bound-polysaccharide and mucoprotein was observed in cases of collergen disease, malignant neoplasm, metastatic neoplasm of liver, uraemia and bacterial or nonbacterial infection. And so ratio of protein-bound-polysaccharide and mucoprotein was high especially in case of liver cirrhosss. 3. Increase of protein-bound-polysaccharidle and decrease of sialic acid and mucoprotein were obse rved in cases of parenchynratous liver disease. 4. Though serum sialic acid and mucoprotein decrease in lipoid nephrosis, decrease of protein-bound-polysaccharide was not found. 5. Allmost all of the serum positive for C-reactive protein had high sialic acid levels. 6. The authors experiments suggest thah sialic acid is related more likely to protein-bound-polys-accharide than to mucoprotein. 7. Clinically and experimentally, changes of those serum glycoprotein levels in collergen diseases and in malignant neoplasm by many drugs, especially by abrenocorticosteroids and “anti-neoplasmsub-stances” were studied. Levels of serum glycoprotein became generally lower according to their rate of recovery from their condition.