Abstract
This paper deals with the experimental studies on percutaneous absorption of benzol in mice.
The apparatus for soaking legs of mice into benzol was devised and the effects of benzol on peripheral blood were observed.
After mice were killed by luxation of cervical vertebrae, their histopathological specimens were stained by Hematoxylin-Eosin.
Volume of benzol in the expirated air and the elimination from the soaked location were measured.
The following resuts were obtained.
A. Increasing of the body weight was inhibited during experiment, thereafter body weight increased.
The depilation of the local skin was observed, but after the experiment it recovered gradually.
B. Hematological findings :
There was no significant change in peripheral blood.
C. Histopatological findings :
Remarkable macroscopic changes were not found.
Microscopic changes were observed in the lungs, liver, kidneys, spleen and the soaked legs, but these were not so remarkable.
D. Benzol seemed to be absorbed easily through the skin, and was eliminated from the lungs into the expiratory air and from the local skin.
The elimination by the latter route was considerable.
These results suggest that absorption of benzol through the skin is so slight in mice that its effect is very little.
