Experimental Studies on the Effect of Air Temperature on the Occurrence of Poisoning.

Abstract

The effect of air temperature on the experimental arsenic poisoning in mice was studied. Experiments were made by subcutaneous injection of arsenious acid solution to mice, inbred strain dd, which were acclimatized or non-acclimatized to artificial climate room adjusted at 10°C, 22°C, 32°C, 36°C, and mortality rates, hematological and histopathological findings were observed. The following results were obtained : 1. The non-acclimatized groups showed lower rates of LD₅₀ and tended to die easily of arsenous poisoning at 10°C, and 36°C than at 22°C and 32°C. 2. Hematological findings of arsenaus acid poisoning indicated the decrease of coucentration of erythrocytes, leukocytes and hemoglobin at 10°C and 36°C in the non-acclimatized groups. On their blood picture, lymphocytes decreased, while neutrophilic leukocytes increased. 3. Histopathological findings were circulatory disturbances and degenerative changes in lungs, kidneys, and liver. These changes were more remarkable in the non-acclimatized groups than the acclimatized groups. And also these changes were more remarkable in the 10°C and 36°C groups than in the 22°C and 32°C groups.