うつ病に対する最近の薬物療法

抄録

The effect of psychotropic drugs on depressive states have been studied by many authors. However, there are few which compared these drugs on the basis of same evaluation scale. Three hundred and forty four ambulant depressive patients were treated with 18 psychotropic drugs (from chlorpromazine to amitriptyline) and the effect of these drugs were compared. The results obtained were as follows. 1. Thymoleptica was found to be the most effective drug for “Axensyndrom” of depressive states. 2. Thymoleptica group was the most important drug in the pharmacotherapy of depressive states. But in some cases thymoleptica should be combined with other drugs such as neuroplegica, tranquilizer and psychotonica. Combination with Neuroplegica is particularly effective. 3. In general, psychotropic drugs are effective in the endogenous depressive states. 4. There was no consistent relationship between side effects and therapeutic effects. Psychopharmacological studies would offer important findings that disclose the essential problem of depressive states.