2015 Volume 6 Issue 1 Pages 43-48
We herein report two cases comprising three pregnancies associated with juvenile idiopathic arthritis（JIA）、 The first patient was a 31-year-old female with rheumatoid factor（RF）-positive poly-JIA and systemic lupus erythematosus． She wished to conceive at 27 years of age after undergoing successfull treatment with methotrexate and infliximab． She became pregnant after the discontinuation of these drugs；however，the arthritis flared up． At gestational week（GA）34、 she delivered a baby weighing 982g via Caesarean section due to severe intrauterine growth restriction. She subsequently conceived a second child under conditions of a moderate disease activity despite the administration of etanercept． At GA 25， she delivered a baby weighing 592g via emergent Caesarean section due to preeclampsia， The second patient was an l6-year-old female with RF positive poly-JIA． ADA was discontinued without any flare-ups when unexpected pregnancy was identified． At GA 37，she gave birth to a child weighing 2,932g． Based on our experience， we believe that patients with JIA who are considering pregnancy or who become pregnant should achieve good control of their disease activity with an appropriate form of effective treatment， Intensive obstetric care is also required throughout pregnancy． Furthermore， Pediatric rheumatologists should be careful to check for not only psychological, but also sexual issues，in adolescent JIA patients．
