Weight Loss Intervention before Cord Blood Transplantation in an Obese Patient with Acute Myeloid Leukemia: A Case Study

Ryuichi Kasahara; Takaaki Fujita; Ryohei Jinbo; Tatsuyuki Kai; Yuichi Yamamoto; Shinichiro Morishita; Miki Furukawa; Yutaka Shiga; Hideo Kimura; Masahiko Fukatsu; Kayo Harada; Satoshi Kimura; Takayuki Ikezoe

doi:10.2490/prm.20210018

Ryuichi Kasahara, Takaaki Fujita, Ryohei Jinbo, Tatsuyuki Kai, Yuichi Yamamoto, Shinichiro Morishita, Miki Furukawa, Yutaka Shiga, Hideo Kimura, Masahiko Fukatsu, Kayo Harada, Satoshi Kimura, Takayuki Ikezoe

著者情報

Ryuichi Kasahara
Department of Rehabilitation, Kita-Fukushima Medical Center, Fukushima, Japan
Department of Hematology, Fukushima Medical University, Fukushima, Japan
Takaaki Fujita
Preparing Section for New Faculty of Medical Science, Fukushima Medical University, Fukushima, Japan
Ryohei Jinbo
Department of Rehabilitation, Kita-Fukushima Medical Center, Fukushima, Japan
Tatsuyuki Kai
Department of Hematology, Kita-Fukushima Medical Center, Fukushima, Japan
Yuichi Yamamoto
Department of Rehabilitation, Kita-Fukushima Medical Center, Fukushima, Japan
Shinichiro Morishita
Department of Rehabilitation, Niigata University Health and Welfare, Niigata, Japan
Miki Furukawa
Department of Hematology, Kita-Fukushima Medical Center, Fukushima, Japan
Yutaka Shiga
Department of Hematology, Kita-Fukushima Medical Center, Fukushima, Japan
Hideo Kimura
Department of Hematology, Kita-Fukushima Medical Center, Fukushima, Japan
Masahiko Fukatsu
Department of Hematology, Fukushima Medical University, Fukushima, Japan
Kayo Harada
Department of Hematology, Fukushima Medical University, Fukushima, Japan
Satoshi Kimura
Department of Hematology, Fukushima Medical University, Fukushima, Japan
Takayuki Ikezoe
Department of Hematology, Fukushima Medical University, Fukushima, Japan

キーワード: cord blood transplantation (CBT), exercise, obesity, weight loss

ジャーナルオープンアクセス HTML

2021 年 6 巻論文ID: 20210018

DOI https://doi.org/10.2490/prm.20210018

詳細

抄録

Background: A severely obese woman (39.8 kg/m²) with relapsed acute myeloid leukemia was admitted to our hospital to undergo salvage chemotherapy followed by cord blood transplantation (CBT).

Case: During the salvage chemotherapy period, a 70-day weight loss program addressing diet and exercise was administered. After the 70-day intervention, the patient’s body weight and body fat mass had decreased (8.6% and 15.0%, respectively) without any adverse events. The number of available cord blood units with total nucleated cells per body weight greater than 2 × 10⁷/kg was zero at admission and two after weight loss; therefore, CBT could be performed.

Discussion: Considering this case, we suggest that a weight loss program combining exercise and nutrition therapy may help patients scheduled for hematopoietic stem cell transplantation by focusing on risk management.

責任著者(Corresponding author)

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