Global warming affects human morbidity, mortality and health. We describe shortly the effects on human health, and focus in malaria as one of the important diseases affected by climatic change. Models on vectors of malaria, i.e. Anopheles, and temperature dependency of sporogonic development of parasites in the mosquito were coupled in order to estimate the eco-climate sensitivity of malaria epidemicity. Combined the models with estimated global climate change pattern of general circulation models, an impact on global human health under intensified malaria risk was assessed and its implication was discussed.