Design and fabrication of an optical microneedles lens array

抄録

Photodynamic therapy (PDT) has been an effective treatment for non-melanoma skin cancer - basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). However, conventional PDT requires high power light irradiation because of light absorption from skin, which could cause damage and hurt. Microneedles have been applied as the light transmission platform for various light therapy to improve the light transmission, but current research on Optical Microneedle Lens Array (OMLA) fabrication with uncertain shape and thickness reduce the productivity and performance of OMLA. In this study, an OMLA for the treatment of the non -melanoma skin cancer was fabricated. The ideal dimension of the device was designed through the ray trajectory simulation. Optimized fabrication method and process were adopted to fabricate OMLA of specific dimension. It is expected that the fabricated OMLA could increase light transmission in PDT process. In this way, PDT performed by OMLA with low hurt could be realized to cure more patients with BCC and SCC.