抄録
The influence of exercise on endogenous levels of both beta-endorphin (BE) and histamine (HT) in hypothalamus were examined in F344 male rats. Rats, six weeks of age, were divided into two groups, involuntary exercised (IE) and control (C). Rats in IE group were exercise on a treadmill running instruments every day for 1 hour at the speed of 20m/min for 7 days. Immediately after training, hypothalamus was obtained from rats killed by decapitation. BE and HT levels in water soluble extracts of the organ was examined by ELISA. We also examined levels of BE and HT in plasma. The amount of BE in hypothalamus obtained from IE-rats was increased by exercise. On the other hand, exercise caused decrease in HT levels in hypothalamus. Although BE levels in plasma was increased by exercise, HT levels in plasma were not affected by exercise. It is reported that histamine in central nerves system exerts the suppressive effects on stress responses. Therefore, the present results may suggest that exercise for 7 days causes increase in BE levels in hypothalamus without stress. [Jpn J Physiol 54 Suppl:S222 (2004)]
