Endocrine-disrupting chemicals and brain function—possible novel target of their action
環境化学物質作用の多様性ー神経細胞膜への作用と転写の修飾機構
詳細
Perinatal exposure to some environmental chemicals such as polychlorinated biphenyls (PCBs) causes adverse health problems particularly in the central nervous system. However, the mechanisms of action has not ye been clear. By using hydroxylated PCB as a model system, we have examined the effect of environmental chemical on cellular function. Low dose of hydroxy PCB induced an expression of c-Jun through activating sodium channel followed by activation of voltage-dependent calcium channel. Lower dose of hydroxy PCB suppressed thyroid hormone (TH) receptor (TR) -mediated transcription by partial dissociation of TR from TH-response element. These results indicate that environmental chemicals may act at multiple site in signal transduction pathway. [Jpn J Physiol 55 Suppl:S38 (2005)]
