抄録
Incidence of cardiovascular diseases is lower in premenopansal women than men. We examined whether gender difference affects tolerance of Mg deficiency mice hearts against ischemia/reperfusion injury. The mice hearts were Langendorff-perfused and subjected to 15 min ischemia /30 min reperfusion. Heart rate, ventricular tension and GOT release were monitored throughout the experiment. Recovery of tension-rate product (TRP) in female mice hearts which perfused with normal Krebs solution or Mg-free Krebs solution was 77.4±3.99% and 66.78±1.63% at 15 min reperfusion, respectively and significantly higher than those in male hearts (66.9±2.78% and 50.9±2.77%, p<0.05, respectively). In mice hearts fed 2-week Mg-deficient diet, TRP of female mice recovered earlier at the beginning of reperfusion than that of male, but there was no difference at the end of reperfusion. In hearts of female mice fed 3-week Mg-deficient diet, TRP recovered to 60.9±9.4% and was not significantly different from that of normal female hearts (p<0.05) when perfused with normal Krebs solution. However, recovery of TRP was significantly lower than that of normal female mice throughout reperfusion when perfused with Mg-free Krebs solution. These results suggest that tolerance of female hearts against ischemia is higher than that of male hearts and the Mg-deficiency can decrease this tolerance. [Jpn J Physiol 55 Suppl:S99 (2005)]
