抄録
Functional mapping of macaque primary visual cortex with implanted multi-electrode array Naohisa Miyakawa1, David Blake2, Michael Merzenich2, Manabu Tanifuji1 1 Integrative Neural Systems, RIKEN BSI, 2 Coleman Lab., KeckCenter for Integrative Neurosci., UCSFIt has been known that in primates, different levels of visual information are processed at different areas within the cortical visual streams. Much remain unknown on how each level of information is processed within each area, but some evidence show possibility of information represented in a distributed manner within the local network of respective cortical areas (Tsunoda et al. 2001). To understand the function of this local network activity, we have developed a chronically implantable multi-electrode array that is laid out in high-density grid configuration with 350 μm spacing. We implanted the array to the primary visual cortex of macaque monkey, and detected multi-unit activity (MUA) from all electrodes for as long as 3 month. We reconstructed a two-dimension functional response map by visualizing the neuronal activity evoked with grating stimuli of different orientations. The map showed significant stability over the 3-month period, indicating that our array is capable of monitoring cortical network activity with minimum damage to the cortical tissue over this period.We will show our preliminary result of multi-electrode array recording of infero-temporal (IT) cortex neurons evoked by natural image stimuli. [J Physiol Sci. 2006;56 Suppl:S177]
