抄録
In the present experiments homeostatic consequences of orbitofrontal cortical (OBF) interleukin-1β (IL-1β) microinjection were investigated. Food intake (FI), water intake and body temperature (BT) were measured after bilateral OBF microinjection and i.p. injection of IL-1β. Metabolic alterations, namely, blood glucose levels (BGLs), plasma concentrations of insulin, leptin, cholesterol, triglycerides and urate were also determined. Similar to consequences of i.p. administration, short term FI was suppressed, whereas BT was raised remarkably after OBF microinjection of IL-1β. Central application of the cytokine led to a diabetes-like prolonged elevation of BGL, furthermore, plasma levels of insulin and triglycerides were found decreased, whereas that of uric acid increased. In our single unit recording study high proportion of OBF neurons were responsive to the microelectrophoretically applied IL-1β. An overwhelming majority of these neurons were also responsive to microelectrophoretically applied D-glucose, i.e., proved to be the elements of the central glucose-monitoring neural network (GMNN). Our findings, therefore, confirm that neocortically organized IL-1β mediated adaptive reactions through the orbitofrontal cortical GMNN play important roles in the central homeostatic control.Supported by: National Research Fund of Hungary (T 042721, M 036687), the Hungarian Academy of Sciences and Richter Gedeon Pharmaceutical Co., Ltd., Hungary. [J Physiol Sci. 2006;56 Suppl:S210]
