抄録
As superoxide and hydroxyl radical have been implicated in pathogenesis of Parkinson disease, free radical scavenging and antioxidant have attracted attention as way to prevent progression. We examined effects of eugenol, an essential oil extracted from clove, on 6-hydroxydopamine (6-OHDA)-induced dopamine reduction in mouse striatum. Eugenol administration 3 days before and 7 more days following one intracerebroventricular 6-OHDA injection prevented reductions of striatal DA and its metabolites and increases of thiobarbituric acid-reactive substances, an indicator of lipid peroxidation. Eugenol did not change catalase, glutathione peroxidase, and superoxide dismutase like activities. Eugenol has known to have superoxide and hydroxyl radical scavenging activities in vitro. These results suggest that eugenol prevents 6-OHDA induced DA depression by preventing lipid peroxidation directly. Effects of eugenol treatment in this model suggest possible value in treatment of Parkinson disease. [J Physiol Sci. 2006;56 Suppl:S211]
