抄録
To investigate neural mechanisms underlying behavioral rule-shift, we trained animals to perform a path-planning task, which required planning of actions in multiple steps of cursor movements to reach a goal by operating manipulanda with either arm. To dissociate the movements of the arms and cursor, we trained the monkeys to perform the task with three different arm-cursor assignments. The assignment was changed without instructions, and the monkeys were required to adapt to new assignments with trial and errors. We recorded neuronal activity from the anterior cingulated motor area, while animals performed the path-planning task. We found neurons that were selectively activated when the assignment was changed. The present findings suggest that the Anterior cingulated cortex is involved in monitoring outcomes of action and updating behavioral rule to be followed. [J Physiol Sci. 2007;57 Suppl:S169]
