抄録
We observed time course of changes in pulse wave velocity (PWV) between carotid and femoral arterial sites and augmentation index (AI) of carotid pulse wave in 20 healthy young subjects during cold pressor test and static handgrip exercise. The cold pressor test was performed following Hines-Brown's method, which required subjects to immerse the right hand in chilly water (4 °C) for 2 min. The static handgrip exercise was performed at 30% of maximal voluntary contraction for 2 min. In the cold pressor test, heart rate (HR) increased maximally during 30-60 s period, whereas mean arterial blood pressure (MBP), PWV, and AI increased maximally during 90-120 s period. During static handgrip exercise, MBP, HR, PWV, and AI increased maximally during 90-120 s period, and returned rapidly toward the control value after the end of exercise. While arterial occlusion of the exercising arm was performing at a cuff pressure of 260 mmHg for 2 min immediately after the end of exercise, which maintains muscle metaboreflex, MBP, PWV, and AI sustained significant increases (P<0.01), but HR returned rapidly toward the control value. These changes in PWV and AI were similar to those in muscle sympathetic nerve activities, as reported by Victor et al (1987) and Saito et al (1990). These results suggest that during cold pressor test and static handgrip exercise, not only peripheral artery but also central artery are under vasomotor control mediated by sympathetic nerve activities. [J Physiol Sci. 2007;57 Suppl:S186]
