抄録
Both exercise and cold stimulation are useful methods to understand the mechanism of increase in blood pressure. The purpose of this study was to investigate the optimum method to produce vasoconstriction selectively in a cold pressure test. Healthy male students served in the following two experiments. 1: In the sitting position at rest, the subject immersed his right fingers in water at a temperature of 19 degrees C. for 1 minute while measuring the blood pressure of the left brachial artery. Fingers, a hand and a forearm were selected as immersing part, and 19, 13, 10 and 6 degrees C. were selected as water temperature. Each cold pressure test was repeated after 5 minutes of interval. 2: In the sitting position at rest, the subject immersed his right hand in water at a temperature of 8 degrees C. for 3 minutes. In the pre-experiment in a middle aged subject, the blood pressure showed 173/113 mmHg by immersion of fingers at water temperature of 6 degrees C. for 1 minute. The blood pressure increased gradually as the temperature became lower, and it was dependent on an increase of calculated peripheral resistance (* stroke volume = mean blood pressure / heart rate). This phenomenon was not remarkable in young subjects. At 2 minutes immersion in water temperature of 8 degrees C., the mean blood pressure increased +10 (7.3-15) mmHg by the increase of vascular resistance without an increase in heart rate. This optimum method of a cold pressure test is useful in the student practice. [J Physiol Sci. 2007;57 Suppl:S187]
