抄録
Low values in plasma lipids and HbA1c were found in the control SHRSP group in the previous study. The continuous rise in blood pressure, which readily results in cerebral stroke, has been said to be the cause for the short life span of SHRSP. In addition to the pressure rise, the low plasma cholesterol level may produce fragile microvessel walls and the short life span of SHRSP. In a similar fashion the plasma membrane of erythrocytes may suffer from the low plasma cholesterol, which shortens the life span of erythrocytes. Measured values in SHRSP are listed here together with reported values in Wistar rats; plasma total cholesterol (TC) 57.3 vs 86.7, LDL 4.5 vs 17.1, HDL 23.0 vs 56.3, TG 45.0 vs 64.7 each in the unit of mg/dl, and HbA1c 0.2 vs 3.41%. Thus, the values in SHRSP are smaller than those in Wistar rats. The life span of erythrocytes are reported 25-40 days in SHRSP and 60 days in Wistar rats. Meanwhile high TC (200-240 mg/dl), and HbA1c (<6%) and a long life span of erythrocytes (120 days) which are larger than those in Wistar are given in human subjects. Since HbA1c represents the cumulative amount of the glycated hemoglobin over the period of 2 months, a comparison of these data suggests that the low value in HbA1c in SHRSP is reasonable because of the small life span of erythrocytes. In addition, SHRSP has genetic disorders also in lipid metabolisms. [J Physiol Sci. 2007;57 Suppl:S210]
