抄録
Urocortin (Ucn), a member of the corticotrophin-releasing factor (CRF) peptide family, has appetite-suppressing and cardiovascular effects. Its intravenous or subcutaneous injection of Ucn reportedly decreased the mean arterial blood pressure (MABP) and increased the heart rate (HR). We report that at 50 and 75 pmol/50 nl, Ucn, suspended in artificial cerebrospinal fluid (ACSF) and microinjected into the rat nucleus tractus solitarii (NTS), produced a significant, dose-dependent reduction in both MABP and HR. Our results suggest that Ucn may act as a neurotransmitter or neuromodulative substance in the NTS and that it may play a role in cardiovascular regulation in vivo. [J Physiol Sci. 2007;57 Suppl:S211]
