抄録
Placenta contains many kinds of cell growth factors and cytokines. The extracts from placenta are used for several kinds of therapy including skin injury. The extracts promote the recovery of skin from injury. As a mechanism, through which the placenta extract promote skin recovery, the cell growth factors system is one of the candidates. In the process of the skin recovery, the blood supply to the injured skin area is important. The effect of placenta extract on blood supply, especially in blood fluidity, is not known. Therefore we investigated the effect of placenta extract on blood fluidity using micro channel array flow analyzer (MC-FAN) method, which mimics blood flow in the capillary vessel. The intra-peritoneal administration of human placenta extract for 4 weeks accelerated the blood fluidity in the case of using heparin as an anticoagulant, but not changed when EDTA was used for the anticoagulant. EDTA blocks both blood coagulation and platelet agglutination. On the other hand, heparin only blocks blood coagulation and does not affect to the platelet agglutination. Therefore placenta extract may improve the blood fluidity through platelet agglutination mechanism. The improvement of blood fluidity might be one of the mechanisms that placenta extract promote recovery from skin injury. [J Physiol Sci. 2007;57 Suppl:S216]
