抄録
Synaptic plasticity in the hippocampus is a fundamental feature of brain function involved in the encoding of information, and the capability of synapses to express plasticity is itself activity-dependent. Numerous studies have identified molecules that are essential for induction and/or maintenance of synaptic plasticities. However, little is know about interaction between the hippocampus and other brain area. The amygdala transfers emotion to various brain regions including hippocampus and there are two kinds of projections to the hippocampus from the basolateral amygdala, direct and indirect pathway via the entorhinal cortex. The modulation is not uniform and ventral hippocampus receives more dense direct innervation, which is sensitive to stress. Activities of the direct and indirect pathways can modulate synaptic transmission in the hippocampus. Activation of locus caeruleus also influenced the transmission. These spatiotemporal and extra-hippocampal modulations of hippocampal synaptic plasticities provide new insights into the function of hippocampus. [J Physiol Sci. 2008;58 Suppl:S35]
