抄録
During food intake, acidic fibroblast growth factor is released from the ependymal cells responding to the increase in glucose from 2-3 to 4-6 mM in CSF. Also leptin increased in plasma enters into the brain. Both first invade into the hypothalamus and suppress food intake, then reach to the hippocampus and facilitate spatial learning and memory. We found recently the facilitation of learning and memory by the twice increased glucose alone in the brain. Namely, the injection of 0.2 ul of 6 mM glucose in the CA1 area in the hippocampus facilitated spatial learning and memory. In vitro experiments, glucose concentration in perfused solution was changed from 3 to 6 mM for 15 min. By this change, the presynaptic release of transmitters and postsynaptic responses for transmitters in CA1 neurons were significantly augmented. Neurochemically by this change significant facilitations of phosphorylations of presynaptic synaptin III and postsynaptic PKC, CaMKII, and extracellular signal-related regulated kinase were occurred. LTP of CA1 neurons was also significantly facilitated by this change with the increased phosphorylation of MARCKS (related to the brain plasticity). These all indicate the significance of food intake for the brain plasticity. [J Physiol Sci. 2008;58 Suppl:S50]
