Abstract
The present study examined the effects of combined treatment with exercise and ARB, Olmesartan, on visceral fat(VFM) and adipocyte cellularity, which induces metabolic syndrome, using the obese model (OLETF) rats. At 25 weeks of age, thirty male OLETF rats were randomly divided into four groups. The exercise treatment consisted of daily exercise. The antihypertensive drug, Olm was given at a dose of 10 mg/kg body weight/day. OLETF-Ex group exercised voluntarily, and OLETF-Ex+Olm group also exercised. Each treatment was conducted between 25 and 30 weeks of age. Abdominal subcutaneous fat (SFM), VFM and skeletal muscles mass (SMM) were weighed. The epididymol fat cell sizes were classified in 20x10(-6)m increments based on the diameter of adipocyte. Exercise and the combination of exercise with ARB reduced abdominal fat masses and improved both GI and dyslipidemia. However, there were no significant multiplicative effects of combing exercise and ARB. Exercise was the most effective in downsizing epididymal fat cells. Treatment with Olm only also significantly reduced BW, downsized adipocytes, and improved GI and dyslipidemia. However, the mechanisms for BW reduction with Olm remain unknown. This study concluded that there were no multiplicative effects of combined exercise with ARB, Olmesartan, on VFM and/or adipocyte cellularity. [J Physiol Sci. 2008;58 Suppl:S97]
