Abstract
Using 131I-triiodothyronine the thyroid function test with 131I-T3 red blood cell uptake and resin sponge uptake were performed for more than 800 blood and 300 sera respectively.
1) Results of the test were as follows: 131I-T3 red blood cell uptake were 11.0-17.5% (average 14.4%) for 18 normal male persons and 8.7-18.5% (average 12.4%) for 96 females: 16.7-35.1% (average 26.7%) for 13 male cases with hyperthyroidism and 12.5-43.3% (average 22.2%) for 87 female cases: 3.1-9.8% (average 7.8%) for 9 cases hypothyroidism: 8.2-17.2% (average 12.3%) for 21 cases of non toxic nodular goiter: 7.5-16.8% (average 12.3%) for 57 cases of non toxic diffuse goiter: 9.3-14.0% (average 11.9%) for 11 cases of malignant goiter: 10.0-21.4% (average 14.6%) for 11 cases of subacute thyroiditis: 9.7-14.9% (average 12.0%) for 14 cases of chronic thyroiditis. 131I-T3 resin sponge uptake were 31.8-41.7% (average 32.0%) for 34 normal females: 45.0-68.5% (average 58.4%) for 35 cases with hyperthyroidism; 20.0-25.1% (average 22.3%) for 5 cases with hypothyroidism; 30.0-39.2% (average 31.5%) for 12 cases of non-toxic nodular goiter; 22.3-36.7% (average 33.0%) for 7 cases of non toxic diffuse goiter; 33.7% for a case of malignant goiter: 30.8% for a case of subacute thyroiditis; 26.2-35.9% (average 30.1%) for 6 cases of chronic thyroiditis.
2) Two tests were compared with 131I thyroidal uptake and basal metabolic rate. They demonstrated less overlapping of the results among the hyperthyroid, normal and hypothyroid persons in comparison to the other 2 tests, and also showed other superior points.
3) In cases with hyperthyroidism which were effectively treated with 131I, results of the test obtained before and after the treatment demonstrated a significant parallelism with clinical symptoms and other laboratory data. Results of the test returned to normal when cured effectively, as the basal metabolic rate responded similarly. In contrast, 131I thyroidal uptake has not been valid often such a treatment given.
4) Two tests demonstrated only slight overlap in those results among hyperthyroid, normal and hypothyroid persons, and thus they are very helpful in diagnosis of various thyroid diseases. Both tests can be done without giving131I to patients, and need only a few milliliters of patient's blood. Since their results are only minimally influenced by exogenous iodide, they are useful in post-therapeutic observation of patients after131I, anti-thyroid agents and thyroid extracts were given.
5) In contrast to131I-T3 red blood cell uptake, 131I-T3 resin sponge uptake need not to worry about hemolysis, it is not influenced by hematocrit values and further it is extremely simple and safe because serum samples are easy to be stored and easy to prevent from contamination.
