Abstract
The previous animal experiments showed that a bovine bile derivative (BBD) (90-95% taurocholic acid) combined with rat globulin localized preferentially in thyroid, stomach as well as in the transplanted Walker 256 carcinosarcoma.
The objective of the present study is to evaluate the clinical applicability of the BBD-IHSA complex. The BBD-IHSA complex, ranging from 130 μCi to 1 mCi, was used on 21 inoperable, histologically verified cancer bearing patients for evaluation of the diagnostic potential. Fifteen cases out of twenty-one were positive, showing increased activity over tumor areas on the scintigram. The scintigram revealed the radioisotopes concentrated not only in tumor but in the thyroid, cardiac area, liver and stomach as well.
Seven positive cases, six of which were considered terminal, were selected for therapeutic uses of the BBD-*IHSA complex. Clinical results are too early to be evaluated, but two cases have distinctly shown the clinical improvement. The results of preliminary therapeutic trials, though inconclusive, indicate a promising approach to cancer therapy.
