RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
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Volume 19, Issue 1
Displaying 1-8 of 8 articles from this issue
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  • Extraction Behavior of Europium with Thenoyltrifluoroacetone (TTA)
    Nagao IKEDA, Kan KIMURA, Hirokazu ASAI, Nobuko OSHIMA
    1970Volume 19Issue 1 Pages 1-6
    Published: January 15, 1970
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.1
    JOURNAL FREE ACCESS
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    The distribution ratios of europium (III) were determined between chloroform containing thenoyltrifluoroacetone (TTA) and 0.1M aqueous perchlorate solution at 25°C, the TTA concentration in the organic phase and the hydrogen ion concentration in the aqueous phase being varied 10-4-10-1 M and 10-3-10-7 M, respectively. The distribution behavior was explained as the extraction of the tris chelate complex into the organic phase and as the formation of the chelate complexes, EuA2+, EuA2+ and EuA3 (A=anion of TTA) in the aqueous phase. The following equilibrium constants were obtained graphically for the respective equilibrium reactions.
    Eu3++3HA (org) _??_EuA3 (org) +3H+ K0=2.95×10-9
    Eu3++A- _??_ EuA2+ β1=4.5×104
    Eu3++2A- _??_EuA2+ β2=4.7×109
    Eu3++3A- _??_EuA3 β3=1.1×1012
    Distribution of Eu (II) was also studied. The distribution ratios for Eu (II) were smaller than those for Eu (III) . It was suggested that the separation of Eu (II) from Eu (III) may be possible at pH 4.2-4.8.
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  • Interaction of Chelating Agents with 203Hg, 115mCd and 65Zn Bound to Protein
    Yukio SUGIURA, Hisashi TANAKA
    1970Volume 19Issue 1 Pages 7-12
    Published: January 15, 1970
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.7
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    The interaction of the chelating agents with the metal bound to protein was investigated by equilibrium dialysis. The chelating agents containing mercapto group such as penicillamine and N-acetylpenicillamine had remarkable effect on the removal of mercury bound to the thiol group of the protein. On the other hand in the case of zinc removal, EDTA and DTPA were more effective compared with the chelating agents containing mercapto group, and a linear correlation was found between the percentage of zinc removed from protein and formation constants of zinc chelates. The percentage of the removal of cadmium correlated to the chelate formation constants in the chelating agents containing mercapto group and in EDTA analogues respectively. The order of the easiness of metal removal in the proteins tested was myoglobin>serum albumin>hemoglobin, regardless the type of the chelating agent. Moreover, the existence of the ternary complex as the intermediate complex in the removal of the metal from the protein was shown by gel-filtration.
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  • IHSA-BBD Complex Affinity for Malignant Neoplasms
    A New Potentially Diagnostic and Therapeutic Radiopharmaceutical
    H.S. Penn, H. Kakehi, N. Arimizu, H. Akiba
    1970Volume 19Issue 1 Pages 13-21
    Published: January 15, 1970
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.13
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    The previous animal experiments showed that a bovine bile derivative (BBD) (90-95% taurocholic acid) combined with rat globulin localized preferentially in thyroid, stomach as well as in the transplanted Walker 256 carcinosarcoma.
    The objective of the present study is to evaluate the clinical applicability of the BBD-IHSA complex. The BBD-IHSA complex, ranging from 130 μCi to 1 mCi, was used on 21 inoperable, histologically verified cancer bearing patients for evaluation of the diagnostic potential. Fifteen cases out of twenty-one were positive, showing increased activity over tumor areas on the scintigram. The scintigram revealed the radioisotopes concentrated not only in tumor but in the thyroid, cardiac area, liver and stomach as well.
    Seven positive cases, six of which were considered terminal, were selected for therapeutic uses of the BBD-*IHSA complex. Clinical results are too early to be evaluated, but two cases have distinctly shown the clinical improvement. The results of preliminary therapeutic trials, though inconclusive, indicate a promising approach to cancer therapy.
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  • Characterization and Discussion of Charge Spectrometer by Means of Ion Beam Experiment
    M. ARATANI, N. SAITO
    1970Volume 19Issue 1 Pages 22-26
    Published: January 15, 1970
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.22
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    1970Volume 19Issue 1 Pages 27-40
    Published: January 15, 1970
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.27
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  • [title in Japanese]
    [in Japanese]
    1970Volume 19Issue 1 Pages 41-60
    Published: January 15, 1970
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.41
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  • [title in Japanese]
    [in Japanese]
    1970Volume 19Issue 1 Pages 61-71
    Published: January 15, 1970
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.61
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  • [title in Japanese]
    1970Volume 19Issue 1 Pages A1019-A584
    Published: January 15, 1970
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.19.A1019
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