Abstract
Under standard clearance conditions, twenty-nine simultaneous measurements of 169Yb-diethylenetriamine pentaacetic acid (169Yb-DTPA) and exogenous creatinine clearances have been performed in dogs, in which renal function was varied by stenosing renal artery.
A good correlation between both groups of comparative studies was found over a wide range of clearance values. (regression equation; y (169Yb-DTPA) =0.933×x (creatinine) +0.5, coefficient of correlation: 0.99) .
However, compared with thiosulfate clearance in twenty-five patients with normal and impaired renal function, 169Yb-DTPA clearance showed lower value than that of thiosulfate. This discrepancy may be probably due to tubular excretion of thiosulfate, because an excellent agreement with 169Yb-DTPA clearance was found when thiosulfate clearance was estimated during high plasma concentration (25mg/dl), and thiosulfate clearance obtained during low plasma concentration (20 mg/dl) averaged 1.2 times as much as that of 169Yb-DTPA.
From these results, it seems that 169Yb-DTPA provides convenient substance for measurement of glomerular filtration rate not only in animals such as dog but in clinical use.
