Abstract
We performed simultaneous GFR clearance method, using 169Yb-DTPA and sodium thiosulfate. The purity of agent and its urinary metabolites of rats were examined by ratio thin layer chromatography using a mixture of acetone and water (1: 1) . The solvent system appeared to be the most suitable from the point of short developing time, proper Rf value and good separating power. Whole body retention of 169Yb-DTPA in female albino rats . was studied for 41 days. While the residue (5%) was excreted very slowly and about 2% of dose still remained even on 30th day. The distribution of 169Yb-DTPA was recognized mainly' in the bone, liver and lung by autoradiogram of mice.
In man, 80-90% of the intravenously administered 169Yb-DTPA was excreted in the urine for the first 2 hours. The renal scintigrams were obtained by administrating 169Yb-DTPA; but the visualization was different from that of 203Hg-chlormerodrin.
In 23 patients, the relative coefficient of 169Yb-DTPA/sodium thiosulfate, (in the terms of clearance) was calculated at 0.98.
