Chemical behavior of recoil60Co in neutron-irradiated cobalt compounds was investigated with a series of cobaltammine salts: [Co (NH3) 6] (NO2) 3, [Co (NH3) 5NO2] (NO2) 2, cis- and trans-[Co (NH3) 4 (NO2) 2]Cl. The distribution of60Co among various species in the solutions of the irradiated salts was dependent upon both the irradiation conditions and the storage conditions after the irradiation. Eighty to ninety percent of60Co was found with the Co (II) fraction when the samples were subjected to chemical separation immediately after the irradiation at dry ice temperature. The percentage distribution of60Co in the fractions other than Co (II) and target species fractions was negligibly small. The irradiation of the samples at ambient reactor temperatures brought about the decrease in the percentage distribution of60Co in the Co (II) fractions. The decrease in the activity of60Co in the Co (II) fraction was accompanied with the increase of60Co. in the fractions of neutral, anionic, cis- and trans-tetrammine-, pentammine- and hexamminecobalt species.
Affinity for the malignant tumor of the lanthanons (140La, 141Ce, 153Sm, 153Gd, 160Tb, 169Yb, 170Tm, 177Lu) was examined. Citrate, chloride or nitrate of these elements was prepared and injected intravenously to the rats which had been subcutaneously transplanted Yoshida sarcoma and these rats were sacrificed 24 hours after injection. The radioactivities of the tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter. The retention values (% dose per g tissue weight) in these organs were calculated. All the compounds which were examined in this experiments had strong affinity for the malignant tumor, and in these eight elements thulium-170 and ytterbium-169 had very strong affinity for the malignant tumor. It is important for the purpose of clinical scanning that the ratio of the concentration of radioactivity in tumor to tissue is large. Tumor-muscle and tumor-blood concentration ratio of thulium-170 and ytterbium-169 were very large and in this respect170Tm- and169Yb-citrate were more excellent than67Ga-citrate. But thulium-170 and ytterbium-169 had very strong affinity for bone, in this respect thulium-170 and ytterbium-169 were inferior to67Ga-citrate. The majorities of injected thulium-170 and ytterbium-169 were accumulated into bone and these elements accumulated into bone were excreted very slowly.
Advances in the treatment of chronic renal failure such as peritoneal dialysis and hemodialysis have made it possible to survive the uremic patients much longer. Success of renal transplantation has obviously served as a life-saving measure in the uremic patients. Recovery of anemia has been observed. But there are few papers which dealt with the metabolism of erythrocytes after the human renal homotransplantation. This paper describes adenine nucleotides and phosphate esters metabolism in red blood corpuscles before and after human renal homotransplantation. Pre-transplant analysis showed the constant increase of ATP, SMP, DPG, and Cell Pi. Incorporation of32P-orthophosphate into SDP, DPG, and Cell Pi was also elevated. In post-transplant analysis, phosphate esters and Cell Pi were decreased. Their32P-orthophosphate incorporation also became normal.
We have measured the triiodothyronine binding capacity of thyroxine binding globulin in blood for the total of 201 cases with a thyopac-3 test. One hundred twenty five cases of them are normal persons, 65 cases are suffering from hyperthyroidism and 11 cases from hypothyroidism. This result indicates that a normal range of thyopac-3 lest in Japan is 95-115. On hyperthyroidism: The present test results correlated quite well with those from 131I-triiodothyronine resin-sponge uptake tests as well as with those from PBI tests. On hypothyroidism: The measurements from this method are more accurate than those from 131I-triiodothyronine resin-sponge uptake test with a very distinct separation marked from those of normal persons. We experienced several cases in which the indications of PBI tests indicated normal values even with known cases of hypothyroidism. In addition to the accuracy in measurements, our new method has the following characteristics: No special temperature control is needed during the entire operation; no strict time control is needed, nor the washing.
We performed simultaneous GFR clearance method, using169Yb-DTPA and sodium thiosulfate. The purity of agent and its urinary metabolites of rats were examined by ratio thin layer chromatography using a mixture of acetone and water (1: 1) . The solvent system appeared to be the most suitable from the point of short developing time, proper Rf value and good separating power. Whole body retention of169Yb-DTPA in female albino rats . was studied for 41 days. While the residue (5%) was excreted very slowly and about 2% of dose still remained even on 30th day. The distribution of169Yb-DTPA was recognized mainly' in the bone, liver and lung by autoradiogram of mice. In man, 80-90% of the intravenously administered169Yb-DTPA was excreted in the urine for the first 2 hours. The renal scintigrams were obtained by administrating169Yb-DTPA; but the visualization was different from that of203Hg-chlormerodrin. In 23 patients, the relative coefficient of169Yb-DTPA/sodium thiosulfate, (in the terms of clearance) was calculated at 0.98.