1974 Volume 23 Issue 4 Pages 224-229
The distribution in the rats and the radiochemical stability of 99mTc-pyrophosphate, 99mTc-polyphosphate and 99mTc-EHDP were investigated. The commercial kits were used for the preparation of these 99mTc-compounds' injections.
There was no pertechnetate as impurity in these injections immediately after the preparation. In these three 99mTc-compounds, about 20% of the injected 99mTc-activity was localized in the skeleton at 2 hours after i.v. injection. Expressed as % dose/g body weight at 2 hours after i.v. injection, bone/blood, bone/muscle, bone/liver and bone/kidney ratios were 11.3, 38.4, 0.7 and 2.3, respectively in 99mTc-pyrophospate, and bone/blood, bone/muscle, bone/liver and bone/kidney ratios were 14.6, 52.1, 1.1 and 1.9, respectively in 99mTc-polyphosphate, and bone/blood, bone/muscle, bone/liver and bone/kidney ratios were 24.2, 153, 46.5 and 3.4, respectively in 99mTc-EHDP. At 4 hours after i.v. injection, these ratios increased in 99mTc-EHDP but were not varied in other two 99mTc-compounds. Bone/callus ratio was 0.6-0.8 from 2 hours to 4 hours after i.v. injection in these compounds.
