Affinity for a Malignant Tumor and Organs at the Elements in Group I of the Periodic Table

Abstract

In order to investigate the tumor affinity radioisotopes, ²²Na, ⁴²K, ⁸⁶Rb, ¹³⁴Cs, ⁶⁴Cu, ^110mAg and ¹⁹⁸Au—the elements of group I in the periodic table—were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Seven preparations, sodium chloride (²²NaCl), potassium chloride (⁴²KCl), rubidium chloride (⁸⁶RbCl), cesium chloride (¹³⁴CsCl), cupric chloride (⁶⁴CuCl₂), silver nitrate (^110mAgNO₃) and chloroauric acid (H¹⁹⁸AuCl₄) were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations but ⁶⁴CuCl₂, 24 hours in ⁶⁴CuCl₂. The radioactivities of the tumor, blood, muscle, liver, kidney and heart were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor) were calculated in percent of administered dose per g-tissue weight.
^110mAgNO₃ had considerably strong affinity for the malignant tumor. All preparations but ^110mAgNO₃ did not have any affinity for malignant tumor. The distribution of ⁴²KCl in the rats very differed from that of ²²NaCl, and was similar to the those of ⁸⁶Rb and ¹³⁴Cs. The distribution of ⁸⁶RbCl in the rats was very similar to that of ¹³⁴CsCl.