Abstract
By using adrenal microautoradiography in rat, we clarified the selective localization in rat adrenal gland of three adrenal specific compounds, 19-iodocholest-5 (6) -en-3β-ol (CL-19-131I) synthesized by Counsell, et al. 6β-iodomethyl-19-nor-cholest-5 (10) -en-3β-ol (NCL-6-131I) derived from CL-19-I by Kojima, et al. and 6β-methyl-19-nor-cholest-5 (10) -en-3β-ol (NCL-6-MeT) first synthesized by Kojima, et al.
And we discussed the usefulness as a possible adrenal scanning agent about these three chemiclas.
1) CL-19-131I:
Two and seven days after 50μCi intraperitoneal injections, there was seen low activity in all zones of cortex and none in medulla.
2) NCL-6-131I:
Two and seven days after injections, there was seen high accumulation of radioactivity in the cells of zona fasciculata and reticularis.
Two days after injection in medulla, high accumulation was also seen.
From these two data it is evident that NCL-6-131I is more usefull for adrenal scintiscanning agent than CL-19-131I.
3) NCL-6-MeT:
Seven days after 50μCi intraperitoneal injection, there was seen high concentration of radioactivity in all zones of cortex and medulla.
