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Volume 25, Issue 2
Displaying 1-12 of 12 articles from this issue
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Kinichi HISADA, Kazuhiko KOJIMA, Tetsuji KOBAYASHI, Tohru SUGITA, Eiji ...1976 Volume 25 Issue 2 Pages 71-75
Published: February 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSRecently application of semiconductors has been noted as one of methods to obtain γ-ray image of better resolution. It is well known that semiconductors have much better energy resolution than scintillators, because they can detect incident γ-rays by transforming directly to electrical signals. And spatial resolution for detecting incident positions of γ-rays should be also improved by the constitution of electrodes cut on the surface of the semiconductor.
So we tried to make a semiconductor gamma camera for developing better γ-ray images with these advantages. The semiconductor for radiation detector was based on ultrahigh purity germanium (p type, concentration of impurity was 2×1010 cm-3, and 30×30 mm2), was constructed p-i-n type, and the electrodes with 10×10 channels orthogonal matrix were cut on its surface.
In this paper the properties of the semiconductor gamma camera with ultra-high purity germanium were described, for example, uniformity, resolution of images and so on.
But as the detector area was very small (about 30×30 mm2), the large object was moved to be imaged partially.View full abstractDownload PDF (5412K) -
T-4 RIA KitHisashi BUNKO, Kinichi HISADA1976 Volume 25 Issue 2 Pages 76-81
Published: February 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSMeasurement of serum thyroxine (T4) as well as triiodothyronine and thyroid stimulating hormone is necessary for management of patients with various thyroid disorders. From the pioneering study of Ekins, Murphy and others, CPBA (competitive protein binding analysis) become one of the most useful and simple method of measuring T4. However, recent successful production o f antiserum to thyroxine, one of the iodoaminoacids, permitted development of several T4 radioimmunoassay procedures. The authors tried to evaluate one of these T4 radioimmunoassay procedures, T-4 RIA kit, and studied basically and clinically.
T-4 RIA kit is based on single antibody radioimmunoassay and utilizes resin-sponge to separate free T4-125I from incubation mixture. The use of sodium salt of trichloroacetic acid (TBG inhibitor) permits direct radioimmunoassay of T4 without tedious extraction procedure. T-4 RIA kit needs only 0.05 ml of patient serum and one hour of incubation to measure T4. TBG inhibitior was equivalent to 5.1pg% of T4 in displacing radioactive T4 from TBG in a CPBA (Res-O-Mat T4) system. And TBG inhibitor volume of 0.5 ml (ten times of serum) was needed to measure high T4 concentration serum. Change of incubation temperature more affected on standard curve than that of incubation time. However, in the case of measuring one hundred samples it took about fifteen minutes to pipette or aspirate and wash all the tubes, and strict control of incubation time was important to maintain accuracy of measurement.
Correlation of T4 value measured by between radioimmunoassay and CPBA in 69 patients was good (r=0.88612, p<0.01) and showed slightly higher T4 value when measured with radioimmunoassay than CPBA (linear regression function: Y=1.17506+0.95766X) . Correlation of T4measured by between Compu-curve and conventional standard curve was excellent (r=0.9995), but slight difference was found in both low and high T4 concentration. In the euthyroid patients without thyroid diseases, T4 concentration was 9.92±2.66 (SD) μg% and normal range was between 4.60 and 15.24 μg%. Reproducibility within assay was 9.9% (CV) and recovery rate was 70% when added 10 ug of T4 and 86% when added 15 μg% of T4. From these results, the authors concluded that radioimmunoassay of serum T4 using T-4 RIA kit would be promising one, especially when measuring large amount of samples at one assay.View full abstractDownload PDF (592K) -
Kenji SAEGUSA, Guio UCHIYAMA, Masanao KAWANA, Yoshio KUNIYASU, Shikie ...1976 Volume 25 Issue 2 Pages 82-88
Published: February 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSCyclotron-produced 123I has short half-life (13.3 h) and an optimum gamma ray energy for scintigraphy (159 keV) . It makes radiation dose to the thyroid as low as nearly one hundredth of 131I. The purpose of this study is to evaluate 123I for clinical use in place of 131I. Thyroid uptake measurements were performed with the standard techniques at 3 and 24 hours after oral administration of radioiodine, and the thyroid scintigraphy were made by a rectilinear scanner or a scintillation camera. Thyroid uptakes of 123I did not coincide so well with 131I when the measurements were performed one after another, but they coincided very well when patients were given both radioiodine simultaneously and measured by the double tracer technique. Thyroid scintigrams of 123I were as excellent as those of 131I except a few cases showed slight increment of the background density. The radioactivity of 123I in the thyroid at 3 hours decays one third in 24 hours. Of 64 patients studied, 59 or 92% showed higher count rate in the thyroid region at 3 hours than 24 hours. The thyroid scintigram using 123I, therefore, is better to be made in 3 to 6 hours while the radioactivity well remains in the thyroid tissue. Iodine-123, instead of I-131, will soon be in use for the thyroid studies in our country.View full abstractDownload PDF (5441K) -
Fumio UMEDA, Minoru MAEDA, Hiroshi OGAWA, Masaharu KOJIMA1976 Volume 25 Issue 2 Pages 89-93
Published: February 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSBy using adrenal microautoradiography in rat, we clarified the selective localization in rat adrenal gland of three adrenal specific compounds, 19-iodocholest-5 (6) -en-3β-ol (CL-19-131I) synthesized by Counsell, et al. 6β-iodomethyl-19-nor-cholest-5 (10) -en-3β-ol (NCL-6-131I) derived from CL-19-I by Kojima, et al. and 6β-methyl-19-nor-cholest-5 (10) -en-3β-ol (NCL-6-MeT) first synthesized by Kojima, et al.
And we discussed the usefulness as a possible adrenal scanning agent about these three chemiclas.
1) CL-19-131I:
Two and seven days after 50μCi intraperitoneal injections, there was seen low activity in all zones of cortex and none in medulla.
2) NCL-6-131I:
Two and seven days after injections, there was seen high accumulation of radioactivity in the cells of zona fasciculata and reticularis.
Two days after injection in medulla, high accumulation was also seen.
From these two data it is evident that NCL-6-131I is more usefull for adrenal scintiscanning agent than CL-19-131I.
3) NCL-6-MeT:
Seven days after 50μCi intraperitoneal injection, there was seen high concentration of radioactivity in all zones of cortex and medulla.View full abstractDownload PDF (5248K) -
Tsuneo SASAKI, Akiko OHNO, Yoshiaki TANAKA, Motoo OHSHIMA, Kazuhito MA ...1976 Volume 25 Issue 2 Pages 94-97
Published: February 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSThe adrenal scintiphotography is performed on the 7th, 8th and 9th day following the intravenous administration of 1 mCi of 131I-adosterol by Nuclear-Chicago Pho Gamma III or Ohio-Nuclear 100 scinticamera. The cases subjected to study are 10 cases of primary aldosteronism and 10 suspected, 4 cases of Cushing syndrome and 3 suspected, and 2 cases of pheochromocytoma and 11 suspected.
The lesions are clearly demonstrated as an hot spot, in all operatively verified cases of primary aldosteronism, Cushing syndrome, and pheochromocytoma respectively.
The normal adrenal glands, are either normally visualized or not visualized. In the primary aldosteronism, the lesions visualized are ranged in the size of 13 to 27 mm. In the Cushing syndrome, the lesions visualized are ranged in the size of 20 to 38 mm. In the pheochromocytoma, the lesions visualized are 40 mm in diameter.
The adrenal scintiphotographic study is useful to detect the lesions and/or to determine the side of lesion before the angiographic examination.View full abstractDownload PDF (2286K) -
Kazuta KITAHARA, Yoshitaka KUGA, Kumiko HARADA, Atsushi SUGII1976 Volume 25 Issue 2 Pages 98-101
Published: February 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSIn order to elucidate the relation between radiolysis and chain length of the materials, γ-radiolysis of three series of the saturated carboxylic acids, their methyl esters and dicarboxylic acid dimethyl esters has been studied in a liquid state. It was found that unreacted fractions of materials (Y) decrease exponentially with an increase in chain length (n) in each series. Variation of G (-M) with carbon numbers was also discussed.View full abstractDownload PDF (314K) -
Nagao IKEDA, Kan KIMURA, Riki SEKI, Hideharu FUJIMOTO1976 Volume 25 Issue 2 Pages 102-104
Published: February 15, 1976
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (273K) -
Yoshihide KONDO1976 Volume 25 Issue 2 Pages 105-108
Published: February 15, 1976
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (438K) -
Shin-ichi SHIMODA, Katsusuke TAKIZAWA, Etsuko MORI1976 Volume 25 Issue 2 Pages 109-111
Published: February 15, 1976
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (294K) -
Inosuke KOYANO1976 Volume 25 Issue 2 Pages 112-121
Published: February 15, 1976
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (1206K) -
(III) Cross Check[in Japanese]1976 Volume 25 Issue 2 Pages 122-128
Published: February 15, 1976
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (810K) -
1976 Volume 25 Issue 2 Pages A1603-A1154
Published: February 15, 1976
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (3683K)
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