USE OF HYDROGEN PEROXIDE AND PEROXYL RADICALS TO INDUCE OXIDATIVE STRESS IN NEURONAL CELLS

Abstract

Reactive oxygen species accumulation has an established role in aging-related diseases, particularly in neurodegenerative diseases; however, its role remains incompletely elucidated. Considering the increasing elderly population, especially in developed countries, proper management of aging-related diseases has become essential and, research on antioxidant therapies is flourishing. Neuronal cells are at the center of oxidative stress research, where studies are being conducted to develop preventive or curative treatments against neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. A panel of pro-oxidants can be used to induce oxidative damage in neuronal cells in vitro. In this mini-review, the use of hydrogen peroxide and 2,2′- azobis (2-amidinopropane) dihydrochloride -generated peroxyl radicals to induce oxidative stress in neuronal cells is discussed.