Wood plastic composite is a relatively new generation of composite material prepared from wood flour, particles, or fibers combined with thermoplastic materials under specific heating and pressure conditions. Wood plastic composite has several advantages, such as ease of maintenance, high durability, and long service life. It can be produced from recycled materials, and several additives can be added to improve its properties. The characteristics of the filler used for manufacturing wood plastic composite influence the physical and mechanical properties of the obtained composite. Filler materials include wood-based filler, other natural fibers, and recycled materials. The composition of the raw material affects the mechanical properties of wood plastic composite. As increasing particle size, melt flow index, flexural and tensile strength, flexural and tensile modulus, heat deflection temperature, and notched impact energy of the composites increase. Chemical treatments such as treatment with NaOH, dilute HCl solution, and chromated copper arsenate can be applied to improve the mechanical properties of wood plastic composite.
RNA interference (RNAi) has emerged as a critical tool for genetic therapeutics. Within the last two decades, there have been extensive investigations in the systemic delivery of these drugs but the obstacles in in vivo delivery have possessed a great difficulty in their administration. These developments led to the advances in systemic administration with designing and incorporation of various drug carriers, including bioconjugate systems, polymeric complexes, organic and inorganic nanoparticles. However, successful translation of these drug delivery systems for the clinical application has still been a great setback for these class of pharmaceutics. In order to improve their competency and applicability, systemic evaluation of currently available carrier systems is required. In this review, we focus on the obstacles in the systemic administration of small interfering RNAs (siRNAs) and the advances with various carrier systems to overcome the limitations of these obstacles. General obstacles in siRNA delivery have been discussed with major emphasis on the barriers at different stages of systemic administration. Then, advances in their application for targeted delivery with rationally designed carrier systems such as bioconjugates, polymeric complexes, and nanoparticles have been introduced. Lastly, we discuss the progress and state of clinical studies of siRNA therapeutics with perspectives of clinical potential.
Potato (Solanum tuberosum), is the most consumed vegetable in Bangladesh throughout the year round. Due to the suitable environment, potato production is increased day by day and in 2019 Bangladesh became the seventh largest potato producing country in the world. Now the amount of production is more than the demand and hence from recent few years Bangladesh starts to exports potato and its associated food products to the different countries in the world. Unemployment problem is very common in the developing countries like Bangladesh but potato gives an opportunity to solve the problem and also help to eradicate the situation of hunger. Though bumper harvest of potato is very common in Bangladesh but the growers are sometimes devoid of to get the fair price due to the extreme margin by the middlemen. Hence, the aim of this study is to examine the present situation of potato production, storage, marketing system, and export. The major findings of this study are as follows: Firstly, poor transportation system, inadequate storage facilities, lack of capital, lack of knowledge of farmers about market price, illiteracy, and syndicate system of middlemen are some key factors for inefficient marketing system of potato in Bangladesh. Secondly, giving the increased important in potato is not the ultimate solution, instantly improve the marketing mechanism of potato is required for Bangladesh. Finally, it is exigent that government needs to take the obligatory steps for the sustainable production and marketing system of potato in Bangladesh.
Melanin, a major pigment in mammalian skin, is known to protect the skin against harmful effects of ultraviolet (UV) irradiation, oxidative stress, and DNA damage. The accumulation or over production of melanin can cause esthetic problem as well as serious diseases related to hyperpigmentation. Tyrosinase, is a copper-containing enzyme which catalyses two rate–limiting reactions in melanogenesis: the hydroxylation of monophenols to o-diphenols, and the oxidation of o-diphenols to o-quinones. Therefore, inhibition of tyrosinase, is the prime target for researchers to regulate melanin production. Tyrosinase inhibitors with high efficacy and less adverse side effects, have huge demand in cosmetic and medicinal industries due to their preventive effect on pigmentation disorders as well as skin-whitening effect. In this review, we focus on the recent advances of tyrosinase inhibitors from all sources, including synthesized compounds, natural products, virtual screening and structure-based molecular docking studies; by categorized into two parts, mushroom and human tyrosinase inhibitors.