Relationships among Adverse Events, Physical Condition and Exercise Therapy Effect in Patients with Blood Tumors during Chemotherapy

Abstract

[Purpose] To consider relationships among adverse events and physical condition and exercise therapy effect in patients with blood tumors during chemotherapy. [Participants and Methods] The participants were patients with blood tumors in hospital for chemotherapy who were prescribed rehabilitation. The evaluation items were: the Cancer Functional Assessment Set (cFAS) and motor Functional Independence Measure (mFIM) as exercise effect indicators, and the Geriatric Nutritional Risk Index (GNRI) as nutrition indicators. The evaluation items of adverse events were 18 items of the Common Terminology Criteria for Adverse Events v5.0 (CTCAEv5). All were evaluated before and after the exercise therapy. The relationship among number of adverse events and cFAS, mFIM and GNRI was analyzed. [Results] There were significant improvements in cFAS and mFIM. Negative correlations were found between the number of adverse events and cFAS, mFIM and GNRI. [Conclusion] The results suggest the possibility of relationships between onset of adverse events and physical function and nutritional status. They also suggest the possibility of exercise therapy benefiting basic movements, activities of daily living, mobility and standing balance regardless of the degree of adverse events or nutritional status.