Abstract
We have investigated the morphological and functional changes of basophilic leukocytes seen in the patients with blood dyscrasias and allergic disorders, and have obtained the following results.
An acute exacerbation seen in the patients with chronic myeloid leukemia can be indicated by the changes in basophilogram. Here, we grade the basophilogram according to the numbers of granules in basophilic leukocytes.
Changes in basophils are closely related to allergic reaction, for instance, asthmatic attack especially of the reagin type. No quantitative relationship was noticed between the numbers of basophils and amounts of IgE.
Specific immunological bindings of basophils to IgE can be seen most conspicuously in the cases of bronchial asthma, whereas these bindings are far less marked in healthy individuals and very weak in chronic myeloid leukemia patients.
Basophils can be found at the very site of the reagin type allergic reactions. This is well demonstrated in skin vesicle tests in which one can see numerous accumulated basophils.
Heparin contained in basophils will suppress the reagin type reaction. Thus, the basophils may control provocations of as well as reparings of allergic reaction.
