Abstract
(I) The changes in the number of basophilic granulocytes in ear-venous blood of rabbits after injection of bovine serum albumin (BSA) to male rabbits non-treated or sensitized with BSA were studied. The results are as follows.
1. Basophilic granulocytes in the rabbits to which BSA were intravenously or subcutaneously injected once (the first sensitization) increased in number from +200% to +500% at 30 or 60 minutes later.
2. From 15 to 30 minutes after injection of BSA in the rabbits previously sensitized with BSA, the counts of the basophilic granulocytes dropped to nearly -100%, then increased in number.
3. A decrease of basophilic granulocytes caused by antigen-antibody reaction with BSA was also observed in vitro.
(II) 1032 patients which in our hospital were examined peripheral basophilic granulocytes by the direct method.
1. Patients The number of pasophilic grannlocyes in given steroid hormone were below normal range.
2. In the cases with eosinophilic granulocytosis or appearance of atypical lymph in the peripheral blood, many basophilic granulocytosis were seen.
3. In the patients with bronchial asthma, tuberculosis and usual infectious disorders, basophilic granulocytes frequently increased in number.
On the other hand, in the patients with collagen diseases, a significant decrease of basophilic granulocytes was observed.
4. The marked basophilic granulocytosis was seen for 100 to 120 days in the postsplenectomized patients with idiopathic thrombocytopenic purpura.
The findings of the basophilic granulocytosis or granulocytopenia mentioned above were discussed in relation to immune reactions.
