成人急性白血病難治症例の検討

—多剤併用療法施行例の反省—

抄録

Twenty-four cases of acute leukemia in adults treated with various combinations of drugs during recent three years were retrospectively analyzed from the standpoint of prognosis.
The patients over the ae of 50, with high levels of circulating leukemic cells and advanced neutropenia (below 500/cumm.), or those complicated with infection at the beginning of treatment opprly responded and took a rapid fatal course. In these refractory variants, risk of infection increased and life seemed to be shortened by employment of combination chemotherapy. The main cause of death was infection and the most frequent pathogenes were geram-negative rods.
Several factors which contribute to the refractoriness in adult leukemia have been discussed and some therapeutic procedures to these refractory variants have been proposed.