小児急性単球性白血病のDaunomycinによる治療成績

—とくに電顕細胞化学的観察を中心に—

抄録

Two children with acute monocytic leukemia (Naegeli type) were treated with Daunomycin and achieved complete remissions. The remissions lasted only 3 weeks and 3 months respectively. Limiting toxicity included thrombocytopenia, oral ulceration, alopecia and sinus arrhythmia.
Ultracytochemical changes in bone marrow leukemic cells, induced by Daunomycin administration, were observed. Particular emphasis was placed on the nucleoli which reduced roundly in size, and the disintegrated nucleolonema was filled with only fine granules. Peroxidase and acid phosphatase activities decreased slightly in intensity in the nuclear envelope and the cavity of granular endoplasmic reticulum, but not in the azur granules. Abundant, irregularly shaped granules with in tensive acid phosphatase activity developed around the Golgi area in a large number of cells.
The relation between such ultracytochemical changes and cytotoxic action of Daunomycin in the literature was briefly discussed.