症例
糖尿病と高血圧の経過中に発症した急性赤血病の1例
1972 年 13 巻 6 号 p. 981-986
詳細
1972 年 13 巻 6 号 p. 981-986
The patient was 55 years old male, and diagnosed as diabetes and hypertention. Since 4 years, he was successfully treated with tolbutamide (sulfonylurea group) and hydroflumethiazide or cyclopenthiazide (thiazide group).
Four years later. he was admitted to this hospital with chief complaints of the gingival hemorrhage and general fatigue. Examination of the blood showed anemia, thrombocytopenia and leucopenia with erythroblast hyperplasia and no young myeloid cells. The marrow showed no myeloblast and hyperplasia of the erythroblast (almost 70% of whole cells), particularly urerythroblasts, megaloblastoid cells and these naked nucleus cell.
The patient who was diagnosed as acute erythremia from these findings, was given blood transfusion, corticosteroids and 6-mercaptopurine for 5 months and died.
Some discussions were done about the correlation between sulfonylureas, thiazides and the occurance of the blood dyscrasias in this paper.
