症例
経過中C-monosomyの染色体異常を来した慢性骨髄性白血病
—特に治療面からの考察—
1973 年 14 巻 11 号 p. 1109-1113
詳細
1973 年 14 巻 11 号 p. 1109-1113
A 42 year old male was admitted after diagnosis of CML on July, 1969. He received Myleran therapy for three months and was discharged in remission state.
The chromosomal number of bone marrow cells and cells from peripheral blood revealed eudiploidy, on the other hand, Ph1 chromosome was shown positive result of 100% at start of initial therapy. Two years later, he readmitted on July, 1971, because of blastic crisis occured. The Karyotypes have changed hypodiploidy (45), and C monosomy has been observed in 60% of marrow cells. He has had three times partial remissioas by means of the therapy with Prednisolone, 6MP-Riboside, Ara-C, Vincristine and Carbazilquinone. He died of cerebral hemorrhage on Jan, 1972.
The C monosomy-changed cells were observed in 100% at second relapse on Aug, 1971.
Canellos et al,6) have reported on relationship between hypodiploid cell line and response to therapy with Prednisolone and Vincristine.
This case has obtained relative good response not only to Prednisolone and Vincristine, but also 6MP-Riboside, Ara-C and Carbazilquinone in acute blastic crisis, whereas the survival time has confined within seven months.
