抄録
The appearance of diabetes insipidus during the course of acute leukemia is very unusual. In this paper a case of acute myelogenous leukemia with concurrent diabetes insipidus is reported. A 37-year-old male was hospitalized in our clinic with the com plaint of gingival bleeding, headache, high fever, thirst, polyuria and pollakisuria of one month duration. Laboratory data showed; WBC, 2500 with 19% myeloblasts; bone marrow, NCC 83 thousands with 31.2% myeloblasts. The urinary output was 4∼7 L/day with a specific gravity of 1,001∼1.006. Hypertonic saline infusion did not reduce urine volume nor increase plasma ADH value. The administration of pitressin and chlorpropamide normalized both urine volume and specific gravity.
At autopsy, perivascular infiltration of leukemic cells was found within the pituitary stalk and posterior pituitary gland, but not in the hypothalamus.
