A 29 years old male patient of Lymphosarcoma with two kinds of M-Components has been described.
The patient had been admitted to Shin Kokura Hospital because of lymphadenopathy of cervical, axillar and inguinal area. Biopsy of the cervical lymph node has revealed the histological finding of Lymphosarcoma.
During the course of therapy with corticosteroid hormone and cyclophosphamide, two kinds of M-components had appeared in the patient's serum, and had been identified as IgG·κ and IgM·κ by immunoelectrophoresis.
Serum concentration of the patient's immunoglobulin had increased three times for IgG and approximately ten times for IgM by antibody agar plate method.
In ultracentrifugal analysis, however, there had been no increase of 19S component although 7S component had shown remarkable increase.
The dyscrepancy between immunological measurement and ultracentrifugal analysis has been explained by the appearance of IgM with smaller molecular size than usual 19S-IgM. After clinical course of some thirty days the IgM concentration had come down to normal range accompanying the disappearance of monoclonal IgM in immunoelectrophoresis.
The mechanism of the appearance of the two kinds of M-components, one of which was transient, has been discussed.
